Dietary Intake and Plasma Levels of Choline and Betaine in Children with Autism Spectrum Disorders
نویسندگان
چکیده
Abnormalities in folate-dependent one-carbon metabolism have been reported in many children with autism. Because inadequate choline and betaine can negatively affect folate metabolism and in turn downstream methylation and antioxidant capacity, we sought to determine whether dietary intake of choline and betaine in children with autism was adequate to meet nutritional needs based on national recommendations. Three-day food records were analyzed for 288 children with autism (ASDs) who participated in the national Autism Intervention Research Network for Physical Health (AIR-P) Study on Diet and Nutrition in children with autism. Plasma concentrations of choline and betaine were measured in a subgroup of 35 children with ASDs and 32 age-matched control children. The results indicated that 60-93% of children with ASDs were consuming less than the recommended Adequate Intake (AI) for choline. Strong positive correlations were found between dietary intake and plasma concentrations of choline and betaine in autistic children as well as lower plasma concentrations compared to the control group. We conclude that choline and betaine intake is inadequate in a significant subgroup of children with ASDs and is reflected in lower plasma levels. Inadequate intake of choline and betaine may contribute to the metabolic abnormalities observed in many children with autism and warrants attention in nutritional counseling.
منابع مشابه
Comparison of dietary intake of vitamin A in children with autism spectrum disorders with healthy children in Gorgan city in 1400, a case-control study
Autism spectrum disorder (ASD) is a multifactorial disorder that is affected by genetic and environmental factors, including nutritional factors. Recently, the role of nutrients, especially vitamin A, in the pathophysiology and treatment of ASD has received increasing attention. In addition, ASD affects the nutritional pattern and therefore some nutrients may not be received enough. This study ...
متن کاملThe Evolution of Social Cognition Development in Children whit Autism Spectrum and ADHD Disorders: A Systematic Review Study
Autism spectrum and attention-deficit/hyperactivity (ADHD) disorders are associated with widespread social cognitive impairments that affect their social relationships. In this regard, the present review study was conducted to investigate the development of social cognition in children with autism spectrum and ADHD disorders. In this systematic meta-analysis study, published articles on the dev...
متن کاملNutritional and Dietary Interventions of Autistic Spectrum Disorders: A Short Review
Autism spectrum disorder (ASD) is a neurodevelopmental condition of heterogeneous etiology, categorized by social communication deficits, repetitive or restrictive behaviors and interests. Epidemiological studies display that the incidence of autism is increasing, and the treatment of autism is vitally important. There...
متن کاملDietary Garlic Powder Supplementation Could Ameliorate Unfavorable Effects of Choline Deficiency on the Liver Health and Immune System of Broiler Chickens
Effects of different levels of choline and garlic powder on performance, liver health and immune response in broiler chickens were evaluated in this study. A factorial experiment with 2 dietary choline levels (the recommended level in Ross 308 broiler guidelines and 25 % less than the recommendation) and 3 dietary garlic powder levels (0, 5 or 10 g/kg diet) was conducted using Ross 308 broiler ...
متن کاملThe Effects of Individual and Group Training on General Health and Stress of Parents of Children with Autism Spectrum Disorders
Objectives: This study compared the effects of individual and group training on general health and stress of parents of children with Autism Spectrum Disorders. Methods: A sample of 75 parents of children referring to Autistic Children Foundation (including 50 parents in two experimental groups and 25 parents in control group) was taken into account. Sample parents were selected through Acce...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
دوره 2013 شماره
صفحات -
تاریخ انتشار 2013